- Leukaemia cells at diagnosis are present in the CSF in only 3-7 % of patients, however over 50% will eventually develop CNS leukaemia. CNS prophylaxis is therefore administered to all patients to prevent leukaemia cells spreading and causing a relapse. It is commonly given throughout the whole treatment period.
- Chemotherapy drugs are given orally or intravenously will not be able to penetrate the CNS, so they are injected into the CSF via a lumbar puncture. This is called intrathecal therapy.
- Following the lumbar puncture, a hollow needle is inserted between two of the vertebrae in your lower back and the drugs injected into your CSF.
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