Key points

  • Haematopoietic stem cells (HSCs) develop into terminally differentiated myeloid and lymphoid cells through intermediate progenitor cells.
  • The lineage of haematopoietic cells has been extensively studied using flow cytometryand traditional transplantation techniques.
  • The precursors of fully differentiated blood cells have intermediate properties between them and the HSC Developmental potential becomes increasingly restricted as blood cells complete their development.
  • The self-renewal of HSCs is a highly regulated process that provides a continuous source of blood cells in adult humans.
  • Cytokines such as interferon-a and granulocyte–macrophage colony-stimulating factor provide signals to HSCs to proliferate and differentiate.
  • Transcription factors are also vital in the regulation of haematopoiesis.