Structure of CAR-T cells

The chimeric antigen receptor (CAR) on CAR-T cells is a hybrid of the antigen-recognition region of an antibody combined with the underlying machinery of a T cell (Figure 1.2). To understand the CAR, it is necessary to first understand the structure of antibodies and TCRs. 

Figure 1.2 Structure of (a) an antibody, (b) a T cell receptor (TCR) and (c) a T body – an early version of a chimeric antigen receptor. The first chimeric antigen receptors essentially comprised a TCR in which the variable regions were exchanged for antibody variable regions.