Minimal/Measurable Residual Disease

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Conventional methods of detecting disease remission in cancers such as leukaemia rely on microscopic analysis of tissue samples. Measurable (or minimal) residual disease describes the presence of disease beyond the levels of sensitivity afforded by microscopy. This course describes what is meant by measurable residual disease, the opportunities and challenges afforded by its identification and the advantages and disadvantages of the methods used for detection. 

We also draw on specific examples to illustrate the implications of detecting measurable residual disease in different disease scenarios, with emphasis on acute myeloid and acute lymphoblastic leukaemias. The recognition and monitoring of measurable residual disease are likely to play an increasingly important role in disease prognosis and subsequent treatment direction – this accessible resource is ideal for any healthcare professional wanting to know more about this exciting and fast-moving area.


For each chapter, we have produced a workbook that you can download and keep. The pass mark for this course is 70%.

Completion of this course will take approximately 3 hours (1 hour per chapter) and the certificates provided can be used towards your revalidation.

For any queries about the content of the MRD course, including references, please email

This content was commissioned by Leukaemia Care and written by Justin Loke BM BCh PhD MRCP FRCPath for Karger publishing.

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