Graft Versus Host Disease (GVHD)

Current Status
Not Enrolled
Price
Subscribe for access
Get Started

GVHD is a condition that occurs in patients who have received an ASCT, and where the graft (stem cells from the donor) reacts against the host (patient receiving the stem cells).

An ASCT involves transplanting healthy stem cells from a suitable matching donor such as a sibling, parent or child into a patient with a blood disorder who needs a transplant

  • The donor stem cells replace the patients’ defective stem cells that have previously been destroyed by treatment with radiation or high doses of chemotherapy, known as the conditioning process. 
  • The donor stem cells replace the patients’ defective stem cells that have previously been destroyed by treatment with radiation or high doses of chemotherapy, known as the conditioning process. 

ASCTs are performed in patients in conditions such as:

  • Acute and chronic leukaemia
  • Myelodysplastic syndromes
  • Aplastic anaemia
  • Non-Hodgkin’s and Hodgkin’s lymphomas
  • Multiple myeloma
  • Haemoglobinopathies (blood disorders that affect red blood cells)

Stem cells from the donor are infused into the patient’s bloodstream, from where they travel to the bone marrow and start creating new blood cells in a process called engraftment.

Donated blood stem cells can be collected from:

  • The donor’s blood
  • The bone marrow within a donor’s hipbone
  • A donated umbilical cord 

ASCTs are associated with about a 50% rate of transplant-related deaths or life-threatening side effects which include GVHD

What will you learn in this module?

  • What is GVHD?
  • What parts of the body does GVHD affect?
  • What is the treatment for GVHD?
  • Nursing challenges in the care of patients with GVHD

A self-assessment test is included at the end for you to assess your knowledge after the module.

We have produced this PDF of the course content to assist you with completing the course.

Time to complete this course: 2 hour

Date of publication: March 2021

Review date: March 2024

This course was written by Isabelle Leach, information writer for Leukaemia Care. It was peer reviewed by Nurse Fiona Heath at Leukaemia Care. The course was also given an external review by two members of the team at Anthony Nolan charity, Dr Jonathan Kay and Nurse Hayley Leonard, for which we are very grateful.

Course Content

Ratings and Reviews

0.0
Avg. Rating
0 Ratings
5
0
4
0
3
0
2
0
1
0
What's your experience? We'd love to know!
No Reviews Found!
Show more reviews
What's your experience? We'd love to know!
Scroll to Top